Impaired cellular contractile function in thiamine-deficient rat cardiomyocytes
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چکیده
منابع مشابه
Impaired cardiac contractile function in ventricular myocytes from leptin-deficient ob/ob obese mice.
The level of the obese gene product leptin is often positively correlated with body weight, supporting the notion that hyperleptinemia contributes to obesity-associated cardiac dysfunction. However, a link between leptin levels and cardiac function has not been elucidated. This study was designed to examine the role of leptin deficiency (resulting from a point mutation of the leptin gene) in ca...
متن کاملImpaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice.
To define the necessity of calcineurin (Cn) signaling for cardiac maturation and function, the postnatal phenotype of mice with cardiac-specific targeted ablation of the Cn B1 regulatory subunit (Ppp3r1) gene (csCnb1(-/-) mice) was characterized. csCnb1(-/-) mice develop a lethal cardiomyopathy, characterized by impaired postnatal growth of the heart and combined systolic and diastolic relaxati...
متن کاملSwimming training attenuates contractile dysfunction in diabetic rat cardiomyocytes.
BACKGROUND Experimental diabetes promotes contractile dysfunction in cardiomyocytes, but the effects of swimming in this disorder are not known. OBJECTIVE To test the effects of a swimming training program (STP) on cardiomyocyte contractile dysfunction in rats with experimental diabetes. METHODS Wistar rats (age: 30 days; mean body weight: 84.19 g) with diabetes induced by streptozotocin (6...
متن کاملCholesterol depletion impairs contractile machinery in neonatal rat cardiomyocytes
Cholesterol regulates numerous cellular processes. Depleting its synthesis in skeletal myofibers induces vacuolization and contraction impairment. However, little is known about how cholesterol reduction affects cardiomyocyte behavior. Here, we deplete cholesterol by incubating neonatal cardiomyocytes with methyl-beta-cyclodextrin. Traction force microscopy shows that lowering cholesterol incre...
متن کاملLeptin Attenuates the Contractile Function of Adult Rat Cardiomyocytes Involved in Oxidative Stress and Autophagy.
BACKGROUND Leptin has been identified as an important protein involved in obesity. As a chronic metabolic disorder, obesity is associated with a high risk of developing cardiovascular and metabolic diseases, including heart failure. The aim of this paper was to investigate the effects and the mechanism of leptin on the contractile function of cardiomyocytes in the adult rat. METHODS Isolated ...
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ژورنال
عنوان ژورنال: European Journal of Heart Failure
سال: 2009
ISSN: 1388-9842
DOI: 10.1093/eurjhf/hfp146